Critical Medicine and Treatment

In patients with stable coronary artery disease, measuring levels of troponin T with methods of high sensitivity analysis may give clues about the chances of developing heart failure or death from cardiovascular causes. The study, published today in The New England Journal of Medicine, suggests that levels of this protein does not affect the chances of these patients developing acute myocardial infarction. After adjusting for independent prognostic indicators with appropriate methods, concentrations of cardiac Troponin T are related Cadiovascular incidence of death and heart failure, but not with acute myocardial infarction in patients with coronary artery disease, according to data from the Peace , whose first

In most patients with stable coronary artery disease, troponin T levels are below the detection limit with conventional analysis. So Omland group has used a highly sensitive study to determine the concentration of troponin T in plasma samples in 3679 patients with stable coronary artery disease and preserved ventricular function. The results of the analysis used show a relationship between the incidence of cardiovascular disease during follow-up period of 5.2 years.

More sensitivity

With the sensitive method used, troponin T concentrations were above the detection limit of 0,001 nanograms per liter in 3593 patients, 97.7 percent, and below the 99th percentile of healthy subjects in 407 patients, 11.1 percent. After adjusting for prognostic indicators, there was an increase in the cumulative incidence of cardiovascular mortality and heart failure in this group.

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